miRdSNP

RNA Type: miRNA

Overview: miRdSNP provides A1:R4a comprehensive data source of dSNPs and robust tools for exploring their distance from miRNA target sites on the 3’UTRs of human genes. miRdSNP enables researchers to explore the molecular mechanism of gene dysregulation for dSNPs at posttranscriptional level. The current release includes 786 dSNP-disease associations for 630 unique dSNPs and 204 disease types. miRdSNP annotates genes with experimentally confirmed targeting by miRNAs and indexes miRNA target sites predicted by TargetScan and PicTar as well as potential miRNA target sites newly generated by dSNPs. Searches can be dynamically filtered by gene name, miRBase ID, target prediction algorithm, disease, and any nucleotide distance between dSNPs and miRNA target sites. Results can be viewed at the sequence level showing the annotated locations for miRNA target sites and dSNPs on the entire 3’UTR sequences.

Search Methods:

• TAG: miRNA, Prediction Method, Disease
• Tabular: refseqs that have both miRNA target sites and disease-associated SNPs; disease-associated SNPs harvested from PubMed
• Keyword: gene, SNP, Distance (nt)

Source: PubMed,UCSC Genome Browser, HapMap Project (LD), SNAP and data from the CEU (CEPH Utah Residents with Northern and Western European Ancestry) population, TargetScan 5.1, PicTar, miRBase, TarBase, miRTarBase, miRecords and miR2disease.

Information Source: Literature, Manual curation.

Information Content: 3'UTR Regions, Disease, Disease-associated SNPs, Single nucleotide polymorphisms, Target site.

Reference: Andrew E. Bruno, Li Li, James L. Kalabus, Yuzhuo Pan, Aiming Yu, Zihua Hu

PubmedID: 22276777.

Year: 2012

Multiple search: Yes

Download: BED, Other.

Genomic Overview: Yes

Organism: Homo sapiens (Human).

Url: http://mirdsnp.ccr.buffalo.edu/