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RNA Type: miRNA
Overview: A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of ‘miRNA pharmacogenomics’ through ‘Pharmaco-miRs’. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. These interactions can be described as triplet sets consisting of a miRNA, a target gene and a drug associated with the gene. We have developed a web server which links miRNA expression and drug function by combining data on miRNA targeting and protein^ drug interactions. miRNA targeting information derive from both experimental data and computational predictions, and protein^ drug interactions are annotated by the Pharmacogenomics Knowledge base (PharmGKB). Pharmaco-miR’s input consists of miRNAs, genes and/or drug names and the output consists of miRNA pharmacogenomic sets or a list of unique associated miRNAs, genes and drugs.We have furthermore built a database, named Pharmaco-miR Verified Sets (VerSe), which contains miRNA pharmacogenomic data manually
curated from the literature, can be searched and downloaded via Pharmaco-miR and informs on trends and generalities
published in the field. Overall, we present examples of how Pharmaco-miR provides possible explanations for previously published observations, including how the cisplatin and 5-fluorouracil resistance induced by miR-148a may be caused by miR-148a targeting of the gene KIT
Information Source: Experimental, In silico annotation, In silico annotation.
Information Content: Database, microRNAs, miRNA pharmacogenomics set, Pharmaco-miR, pharmacogenomics, Web server.
Reference: Rukov et al., 2013
Multiple search: Yes
Genomic Overview: No